2-CHLORO-3-FLUOROISONICOTINIC ACID

Name	2-Chloro-3-fluoropyridine-4-carboxylic acid
Synonyms	2-Chloro-3-FluoroisonicotinicAci 2-chloro-3-fluoroisonicotinic acid 2-CHLORO-3-FLUOROISONICOTINIC ACID 2-Chloro-3-fluoropyridine-4-carboxylic acid 2-chloro-3-fluoro-4-pyridinecarboxylic acid 2-CHLORO-3-FLUOROPYRIDINE-4-CARBOXYLIC ACID 4-chloro-2-nitro-6-(trifluoromethyl)aniline 2-Chloro-3-Fluoroisonicotinic Acid(WX614144) 4-Pyridinecarboxylic acid, 2-chloro-3-fluoro- 2-Chloro-3-fluoropyridine-4-carboxylic acid, 4-Carboxy-2-chloro-3-fluoropyridine
CAS	628691-93-0
EINECS	672-530-6
InChI	InChI=1/C7H4ClF3N2O2/c8-3-1-4(7(9,10)11)6(12)5(2-3)13(14)15/h1-2H,12H2

Molecular Formula	C6H3ClFNO2
Molar Mass	175.54
Density	1.576±0.06 g/cm3(Predicted)
Melting Point	199°C (dec.)
Boling Point	389.1±37.0 °C(Predicted)
Flash Point	118.6°C
Vapor Presure	0.00604mmHg at 25°C
pKa	2.07±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.542
MDL	MFCD04038325

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
Hazard Class	IRRITANT

introduction	2-chloro-3-fluoro-isonicotinic acid is an organic intermediate, which can be prepared from 2-chloro-3-fluoropyridine by reaction with strong alkali and dry ice.
use	2-chloro -3-fluoro-isonicotinic acid is a carboxylic acid organic substance, and it has been reported in the literature that it can be used to prepare ADP receptor antagonist antiplatelet drugs.
preparation	n-butyl lithium (290ml,0.72mol) is added to diisopropylamine (95ml,0.66mol) in a solution of 500ml anhydrous THF under nitrogen at -78 ℃. After stirring for 0.5 hours, the resulting mixture was added to a solution of 2-chloro-3-fluoropyridine (78g,0.60mmol) in 200ml of anhydrous THF at -78°C. after stirring for 3 hours, pour the mixture into dry ice (340g,6.0mol). Dilute the mixture with water (1L) and adjust the pH to about 2 with 2M aqueous hydrochloric acid. The product was extracted with ethyl acetate (3 × 500mL), and the combined extract was washed with brine, dried with Na2SO4, filtered and concentrated, and the solid residue was recrystallized from EtOAc to give the title compound.

Last Update：2024-04-09 21:01:54

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CAS: 628691-93-0
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Email: 2853786052@qq.com
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Product Name: 2-Chloro-3-Fluoroisonicotinic Acid Visit Supplier Webpage Request for quotation
CAS: 628691-93-0
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2-CHLORO-3-FLUOROISONICOTINIC ACID

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